To unlock Big Head Mode (which comically enlarges all of the players heads), you must unlock the Big Head Card. To do so, have the most players named to your leagues all-star squad during any given season. Keep in mind that you must play through at least ten games in their entirety (no simulations) by the All-Star Break.

The epic list below is of all of the player cards in the game. To unlock any given card, fulfil the requirement listed.

• 001 - Doug Davis - Pitch a complete game (and win the game) with Doug Davis (min. 9 inning game).
• 002 - Orlando Hudson - Make 4 defensive assist(s) in a game with Orlando Hudson.
• 003 - Chad Tracy - Get 2 RBI(s) in a game with Chad Tracy.
• 004 - Stephen Drew - Score 2 run(s) in a game with Stephen Drew.
• 005 - Eric Byrnes - Steal 2 base(s) in a game with Eric Byrnes.
• 006 - Brandon Webb - Pitch a shutout with Brandon Webb (min. 7 inning game).
• 007 - Randy Johnson - Get credit for the win and strikeout 8 batters in a game with Randy Johnson (min. 7 inning game).
• 008 - Livan Hernandez - Get credit for a win with Livan Hernandez (min. 7 inning game).
• 009 - Micah Owings - Hit 1 home run(s) in a game with Micah Owings.
• 010 - Jose Valverde - Get credit for a save with Jose Valverde (min. 7 inning game and at least 3 batters faced).
• 011 - Brandon Lyon - Get credit for a hold with Brandon Lyon (min. 9 inning game).
• 012 - Chris Young - Lead-off the game with a home run with Chris Young.
• 013 - Brian McCann - Get 6 total base(s) in a game with Brian McCann.
• 014 - Mark Teixeira - During a season, be named Batter of the Month with Mark Teixeira. You must play (not simulate) every MLB game during a given month.
• 015 - Kelly Johnson - Get 2 base hit(s) and 1 steal(s) in the same game with Kelly Johnson.
• 016 - Chipper Jones - Get 2 extra base hit(s) in a game with Chipper Jones.
• 017 - Edgar Renteria - Get a 2-Out RBI with Edgar Renteria.
• 018 - Andruw Jones - Rob a Home Run (make a wall climb catch) with Andruw Jones.
• 019 - Jeff Francoeur - Make 1 outfield assist(s) in a game with Jeff Francoeur.
• 020 - John Smoltz - Get credit for a win with John Smoltz (min. 7 inning game).
• 021 - Tim Hudson - Pitch a shutout with Tim Hudson (min. 7 inning game).
• 022 - Rafael Soriano - Get credit for a save with Rafael Soriano (min. 7 inning game and at least 3 batters faced).
• 023 - Octavio Dotel - With Octavio Dotel, strikeout all 3 batters in one inning.
• 024 - Tom Glavine - Pitch a 2-hit (or less) complete game and get credit for the win with Tom Glavine (min. 7 inning game).
• 025 - Ramon Hernandez - Throw out 1 runner(s) attempting to steal in a game with Ramon Hernandez.
• 026 - Brian Roberts - Steal 2 base(s) in a game with Brian Roberts.
• 027 - Melvin Mora - During a season, be named Batter of the Month with Melvin Mora. You must play (not simulate) every MLB game during a given month.
• 028 - Aubrey Huff - Get 2 RBI(s) in a game with Aubrey Huff.
• 029 - Miguel Tejada - Get 3 RBI(s) in a game with Miguel Tejada.
• 030 - Corey Patterson - Steal 1 base(s) in a game with Corey Patterson.
• 031 - Nick Markakis - Hit 1 home run(s) in a game with Nick Markakis.
• 032 - Erik Bedard - Strikeout 10 batter(s) in a game with Erik Bedard.
• 033 - Daniel Cabrera - Strikeout 8 batter(s) in a game with Daniel Cabrera.
• 034 - Chris Ray - Get credit for a save without allowing a run with Chris Ray (min. 7 inning game and at least 3 batters faced.)
• 035 - Jay Payton - Make 2 outfield assist(s) in a game with Jay Payton.
• 036 - Chad Bradford - Cause the opposition to swing and miss 3 times with Chad Bradford.
• 037 - Jason Varitek - Have Jason Varitek be named the "Player of the Game."
• 038 - David Ortiz - Hit 2 home run(s) in a game with David Ortiz.
• 039 - Kevin Youkilis - Get 2 RBI(s) in a game with Kevin Youkilis.
• 040 - Dustin Pedroia - Get 2 base hit(s) in a game with Dustin Pedroia.
• 041 - Manny Ramirez - Get 4 RBI(s) in a game with Manny Ramirez.
• 042 - J.D. Drew - Draw 2 walk(s) in a game with J.D. Drew.
• 043 - Daisuke Matsuzaka - With Daisuke Matsuzaka, dont allow a hit in 6+ innings of work.
• 044 - Curt Schilling - Get credit for the win and strikeout 8 batters in a game with Curt Schilling (min. 7 inning game).
• 045 - Josh Beckett - Pitch a shutout with Josh Beckett (min. 7 inning game).
• 046 - Jonathan Papelbon - Get credit for a save without allowing a base hit with Jonathan Papelbon (min. 7 inning game and at least 3 batters faced.)
• 047 - Hideki Okajima - Strikeout a batter on 3 straight pitches with Hideki Okajima.
• 048 - Mike Lowell - Win a Players Choice Best Fielder Award with Mike Lowell. You must play (not simulate) at least 25 MLB games in a season.
• 049 - Derrek Lee - Get 3 base hit(s) in a game with Derrek Lee.
• 050 - Kerry Wood - Strikeout 3 batter(s) in a game with Kerry Wood.
• 051 - Aramis Ramirez - Get 3 RBI(s) in a game with Aramis Ramirez.
• 052 - Alfonso Soriano - Have Alfonso Soriano be named the "Player of the Game."
• 053 - Jacque Jones - Get 2 extra base hit(s) in a game with Jacque Jones.
• 054 - Carlos Zambrano - Hit 1 home run(s) in a game with Carlos Zambrano.
• 055 - Rich Hill - Strikeout 8 batter(s) in a game with Rich Hill.
• 056 - Jason Marquis - Get credit for a win with Jason Marquis (min. 7 inning game).
• 057 - Ted Lilly - Get credit for a win with Ted Lilly (min. 7 inning game).
• 058 - Ryan Dempster - Get credit for a save with Ryan Dempster (min. 7 inning game and at least 3 batters faced).
• 059 - Bob Howry - Strikeout a batter looking (called 3rd strike) with Bob Howry.
• 060 - A.J. Pierzynski - Get 2 extra base hit(s) in a game with A.J. Pierzynski.
• 061 - Paul Konerko - Hit 1 home run(s) in a game with Paul Konerko.
• 062 - Jim Thome - Hit a 425+ foot home run with Jim Thome.
• 063 - Joe Crede - Make 5 defensive assist(s) in a game with Joe Crede.
• 064 - Scott Linebrink - With Scott Linebrink, dont allow a hit in 1+ innings of work.
• 065 - Jermaine Dye - Get 1 extra base hi2000t(s) in a game with Jermaine Dye.
• 066 - Javier Vazquez - Strikeout 8 batter(s) in a game with Javier Vazquez.
• 067 - Mark Buehrle - Get credit for a win with Mark Buehrle (min. 7 inning game).
• 068 - Jose Contreras - Get credit for the win and strikeout 8 batters in a game with Jose Contreras (min. 7 inning game).
• 069 - Bobby Jenks - Get credit for a save with Bobby Jenks (min. 7 inning game and at least 3 batters faced).
• 070 - Jon Garland - Finish a season with Jon Garland having led the league in wins. You must play (not simulate) at least 15 MLB games in a season.
• 071 - John Danks - Pitch a shutout with John Danks (min. 9 inning game).
• 072 - Scott Hatteberg - Score 2 run(s) in a game with Scott Hatteberg.
• 073 - Brandon Phillips - Steal 2 base(s) in a game with Brandon Phillips.
• 074 - Adam Dunn - Hit a 425+ foot home run with Adam Dunn.
• 075 - Josh Hamilton - Hit 1 home run(s) in a game with Josh Hamilton.
• 076 - Eric Milton - Force 10 batters into fly ball outs in a game with Eric Milton.
• 077 - Ken Griffey Jr. - Hit 2 home run(s) in a game with Ken Griffey Jr..
• 078 - Aaron Harang - Get credit for the win and strikeout 8 batters in a game with Aaron Harang (min. 7 inning game).
• 079 - Bronson Arroyo - Pitch a complete game (and win the game) with Bronson Arroyo (min. 7 inning game).
• 080 - Todd Coffey - Strikeout a batter looking (called 3rd strike) with Todd Coffey.
• 081 - David Weathers - Get credit for a save with David Weathers (min. 7 inning game and at least 3 batters faced).
• 082 - Alex Gonzalez - Make a diving stop and throw the runner out in a game with Alex Gonzalez.
• 083 - Victor Martinez - Get 3 base hit(s) in a game with Victor Martinez.
• 084 - Travis Hafner - Hit a Grand Slam with Travis Hafner.
• 085 - Kenny Lofton - Steal 2nd and then 3rd base in one trip to the plate with Kenny Lofton.
• 086 - Jhonny Peralta - Get 2 RBI(s) in a game with Jhonny Peralta.
• 087 - Grady Sizemore - During a season, make the All-Star game with Grady Sizemore. You must play (not simulate) at least 15 MLB games by the All-Star break.
• 088 - Cliff Lee - Get credit for a win with Cliff Lee (min. 9 inning game).
• 089 - C.C. Sabathia - Retire 15 consecutive batters in a game with C.C. Sabathia.
• 090 - Jake Westbrook - Force 8 batters into ground ball outs in a game with Jake Westbrook.
• 091 - Fausto Carmona - Get credit for a win with Fausto Carmona (min. 7 inning game).
• 092 - Joe Borowski - Get credit for a save with Joe Borowski (min. 7 inning game and at least 3 batters faced).
• 093 - Rafael Betancourt - With Rafael Betancourt, strikeout all 3